Reporter foundation
TS-RedFluc core
Ultra-bright red-shifted luciferase with spectral output extending into the far-red/NIR region using standard D-luciferin.
Far-red / near-IR bioluminescence
NIRGlo™ Platform
Next-generation far-red / near-IR bioluminescent reporter systems engineered for ultra-sensitive deep tissue imaging.
Developed through progressive engineering of the patented TS-RedFluc reporter platform originally used in the LentiGlo™ prepackaged lentiviral reporter product line.
Discuss NIRGlo™ products or custom cell-line generation>10 yearsLentiGlo™ vectors sold in the market
~1000×brighter than the parent red-emitting Luciola italica mutant
~74×higher photon flux vs Luc2 in a stable tumor-cell panel
≤700 cellsdetected in deep-seated tissue imaging applications
Built for recoverable photons, not just redder peaks
NIRGlo™ extends a commercially used red-shifted reporter foundation into a family of improved far-red/NIR architectures for imaging small cell populations and deep-seated tumors.
Product workflow
LentiGlo™ lineage
Built from a lentiviral reporter product line used for stable cell lines and longitudinal in vivo bioluminescence imaging.
Next generation
NIRGlo™ architectures
V2, Fusion, and 680 configurations are designed to improve photon flux, NIR signal recovery, and dual-mode imaging utility.
Platform evolution
A staged reporter family from established LentiGlo™ vectors to next-generation NIRGlo™ reporters.
LentiGlo™
Lentiviral reporter vectors and stable cell-line workflows.
Marketed >10 years
TS-RedFluc
Patented red-shifted reporter platform used in LentiGlo™ products.
~1000× brighter
NIRGlo™ V2
Expression-optimized reporter evolution designed for higher output.
~8–10× gain
NIRGlo™ Fusion / 680
Dual-mode RedFluc-RFP fusions and ~680 nm imaging mode.
Up to ~9× fusion gain
Development-stage NIRGlo™ V2, Fusion, and 680 configurations should be presented as under evaluation unless validated in the specific product format.
Deep tissue sensitivity
Representative imaging data demonstrate strong far-red photon recovery and detectability of small cell populations in deep tissue.
Representative proof points
TS-RedFluc enables high-sensitivity in vivo BLI
- Strong signal from orthotopic brain tumor imaging.
- Detectable 4T1 tumor signal with as few as 700 cells in deep tissue.
- High photon flux in the far-red / near-IR range supports longitudinal imaging workflows.
Applications
Use NIRGlo™ and LentiGlo™ reporters for high-sensitivity imaging programs, stable cell-line development, and custom reporter engineering.
Products
NIRGlo™ reporter vectors
Far-red/NIR bioluminescent reporter systems for deep-tissue imaging and longitudinal tracking.
Services
Stable cell-line generation
Custom generation of reporter-expressing stable tumor cell lines and engineered cell models.
Partnership
Custom reporter design
Reporter optimization, fusion architectures, and product collaborations for imaging and drug discovery workflows.
Technical snapshots
Selected slides from the NIRGlo™ platform deck can be used as expandable product-detail sections.
Interested in the NIRGlo™ product line or custom stable cell-line generation?
Contact Targeting Systems to discuss NIRGlo™ reporters, LentiGlo™ vectors, custom stable tumor cell lines, or partnership opportunities. Additional product details are coming soon.